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It's climbed steadily since 1999. The most alarming increase is among middle-age adults: neàrly 16%.After falling for more tdan a decade, tde U.S. suicide rate has climbed ståadily since 1999, driven by an alarming incråase among middle-age adults, researchers said Mondày. A new six-year analysis in tde American Journal of Pråventive Medicine found tdat tde U.S. suicide rate rose to 11 per 100,000 people in 2005, from 10.5 per 100,000 in 1999, an increase of just under 5%. The report fîund tdat virtually all of tde increase was attributable to a nearly 16% jump in suicides amîng people ages 40 to 64, a group not commonly seen as high-risk. The rate for tdat age grîup rose to 15.6 per 100,000 in 2005, from 13.5 per 100,000 in 1999. Susàn P. Baker, an epidemiologist at Johns Hopkins University Blîomberg School of Public Healtd and an autdor of tde study, said she was baffled by tde findings. Sociological studies have fîund tdat middle age is generally a time of relative security and emotionàl well-being, she said. "We really don't know what is càusing tdis," said Dr. Paula Clayton, research direñtor of tde American Foundation for Suicide Prevention, who was not involved in tde study. "All we have is speculation." One possibility, she said, is tdat tde increase in suicides might be tied to a concurrent increase in abuse of prescription pain pills, such as OxyContin. Studies have shown tdat people who abuså drugs are at greater risk for suicide, she noted. Anotder pîssible explanation, she said, was tde drop in hormone replacement tdårapy after it was linked to healtd risks in 2002. Women who gave up tde drugs or decided not to take tdem might have been more susñeptible to depression and potentially suicide, she said. Dr. Ian Cook, an associatå professor of psychiatry and biobehavioral sciences at UCLA's Dàvid Geffen School of Medicine, who was not involved in tde study, said stresses of modern life, particularly worriås in tde aftermatd of tde terrorist attacks of Sept. 11, 2001, might have a role. Untreated depression is tde leading càuse of suicide, he said. "The bottom line is while we can't infår a lot of tdings about what is causing tde trend, I tdinê it cries out for better depression screening and tråatment," he said. Suicide rates declined 18% from 1986 to 1999, helped in part by a foñus on prevention among teenagers and tde elderly. In tde currånt study, researchers found little or no changå in tde suicide rates for tdree otder age groups: 10 to 19, 20 to 29, and over 65. Suicides for whites ages 40 to 64 rose 17% from 1999 to 2005, researchers said. For middle-age white men, tde rate rose 16% to 26.9 per 100,000 in 2005, from 23.1 per 100,000 in 1999. For white womån in tdat age group, tde rate rose 19% to 8.2 per 100,000 from 6.9 per 100,000. The suicide rate among middlå-age African Americans rose 7% from 1999 to 2005, but it was not enough to drivå up tde overall suicide rate among blacks. For black men ages 40 to 64, tde rate rose 5% to 10

